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DEXAMETHASONE INNER EAR PERFUSION BY INTRATYMPANIC INJECTION IN UNILATERAL MENIERE'S DISEASE: SIX YEARS OF PROSPECTIVE FOLLOW-UP
Marco Antonio Garduño-Anaya, Heloísa Couthino De Toledo, Carlo Pane-Pianese
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OBJECTIVE: To evaluate the evolution of vertigo, hearing loss, tinnitus and aural fullness in patients treated with placebo (saline solution) or dexamethasone inner ear perfusion (DIEP) injected intratympanically 6 years ago.■
METHODS: 22 patients were accepted, 11 were treated with DIEP and the other 11 patients with placebo. They were injected intratympanically once a day by 5 consecutive days to the involved ear.The trial was proscpective, placebo-controlled, randomized, double blinded for two years, and then the trial was opened and followed prospectively in an open form.■
RESULTS: Of the 11 patients in the dexamethasone group, one was missing and the other 10 were followed. 60% (6 patients) haven't experience another vertigo, 30%(3 patients) have substantial control of vertigo and 10% (1 patient) have vertigo in the frecuency of one crisis each other two months and had to receive another perfusion of dexamethasone. In the control group one patients was missing. 70% (7 patients) had to receive another sesion of dexamethasone perfusion because of the frecuency of vertigo, 10% (1 patient) have substantial control of vertigo and 20% (2 patients) have complete control of vertigo.■
CONCLUSION: At six years of follow up, dexamethasone inner ear perfusion has better control of vertigo than control.